N-PEGylation of a Reverse Turn Is Stabilizing in Multiple Sequence Contexts, unlike N-GlcNAcylation
نویسندگان
چکیده
منابع مشابه
Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts.
Cotranslational N-glycosylation can accelerate protein folding, slow protein unfolding, and increase protein stability, but the molecular basis for these energetic effects is incompletely understood. N-glycosylation of proteins at naïve sites could be a useful strategy for stabilizing proteins in therapeutic and research applications, but without engineering guidelines, often results in unpredi...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2011
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb200277u